The characteristics of hydrogen generation from catalytic partial oxidation of methane (CPOM) in a reactor were investigated in the present study. The reactor was featured by a Swiss-roll structure in which a rhodium (Rh) catalyst bed was embedded at the center of the reactor. By recovering the waste heat from the product gas to preheat the reactants, it was found that the combustion, steam reforming and dry reforming of methane in the catalyst bed were enhanced to a great extent. As a result, the methane conversion and hydrogen yield were improved more than 10%. Considering the operation conditions, a high performance of hydrogen generation from the CPOM could be achieved if the number of turns in the reactor was increased or the gas hourly space velocity of the reactants in the catalyst bed was lower. Alternatively, the flow direction of the reactants in the reactor almost played no part in affecting the performance if the waste heat was recovered. It is thus emphasized that the reactor with a Swiss-roll structure can be applied for implementing CPOM with high yield of hydrogen.