The novel method of using continuous tribo-electrification variations to monitor the dynamic tribological properties between metal films has been applied successfully by the authors. The method was shown to produce clear and strong signals, superior to monitoring continuous friction coefficient variations. However, the above method was only shown to be suitable for the tested metal pairs that were studied. Therefore, this study investigates the novel method of using electrical contact resistance variations for monitoring the tribological properties and the wear mechanisms of titanium pairs. Moreover, the new method has great potential for monitoring the chemical reactions between the interfaces. The experiment was conducted on a purposed-designed friction tester with a suitable measuring system. In order to investigate the chemical reactions of titanium (Ti) sliding against Ti under water lubrication, the continuous variations of electrical contact resistance and friction coefficient were measured. Wear loss was measured by an accuracy balance and scan electron microscopy was used to observe the microstructures and of material transfer. Therefore, the tribological properties of titanium pairs under water lubrication can be investigated in detail. All of the experimental results demonstrated that the water lubrication has great potential for the research.