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    Please use this identifier to cite or link to this item: https://ir.lib.ksu.edu.tw/handle/987654321/12179


    Title: Estimation Of Macromolecular Drug Diffusivities In Solid Tumors
    Authors: C-T Liauh(廖慶聰)
    H-W. HUANG
    W-J. CHANG(張文進)
    H-L. LEE(李浩榕)
    S-S. HOU(侯順雄)
    W-L. LIN
    Contributor: 機械工程系
    Keywords: Transport Phenomena
    Diffusion
    Pharmacokinetics
    Convection
    Numerical Simulations
    Date: 2010-11-25
    Issue Date: 2010-12-02 10:38:05 (UTC+8)
    Abstract: To effectively deliver drugs to all tumor regions is one of the most current
    important research issues at present. Unfortunately, some of measurements of
    transport properties were infeasible to obtain at present technology and some of
    experimental trails involved complicated tumor microenvironments that were hard to
    analyze. Therefore, the main purpose of this study is to use an optimization scheme to
    seek for optimal macromolecular speed at blood vessel surface and diffusivity. With
    integrating experimental information on dextran covalently linked to a fluorophore in
    tumors, optimization scheme, mathematical modeling and numerical modeling, an
    estimation scheme is proposed to predict several parameters of interest in tumour
    region.
    One-dimensional transient solute transport equation coupled with experimental
    pharmacokinetics data is used in the study. The governing equation, which is derived
    from cylindrical coordinate, includes convection and diffusion modes of transport.
    Results show that comparably convection plays a rather significant role in solid tumor
    than diffusion for larger size of macromolecules and in optimization process to obtain
    solutions of diffusivities and drifting velocities, although it is still weak. The
    computational results show in accordance with figure 6 of Dreher et al’s paper.
    Relation: International Conference on Cellular & Molecular BioEngineering 2010
    Appears in Collections:[機械工程系所] 會議論文

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